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By Robert Lev

Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the gigantic physique of uncomplicated technology and medical facts linked to adenomatous polyps of the colon, a lot of it encouraged via the belief that the majority colorectal carcinomas appear to come up in such polyps. This ebook strives to judge those facts, with specific emphasis on their implications for administration of polyp-bearing matters. subject matters comprehensively explored contain anatomy and histology of the traditional colon; pathologic features of adenomatous polyps, differential analysis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic proof for the malignant capability of adenomatous polyps; and detection and administration, with distinctive consciousness to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.

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Additional info for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features

Sample text

TIssue Culture APs have characteristics intermediate between normal and malignant mucosa. , 1981). This may be because tubular adenomas are the closest of the three to normal colonic cells, and it is known that normal cells are more responsive than transformed cells to exogenous epidermal growth factor (Shields, 1978). The abnormalities that APs do show are generally more numerous when such risk factors for malignancy as significant dysplasia or villous components are present. Chromosomal aberrations are more common in villous than in tubular adenomas, for example.

J Clin Pathol 35:830-841. Kozuka S (1975) Premalignancy of the mucosal polyp in the large intestine. I. Histologic gradation of the polyp on the basis of epithelial pseudostratification and glandular branching. Dis Colon Rectum 18:483-493. Lance P, Lev R (1989) Colonic oligosaccharide structure deduced from lectin-binding studies before and after desialylation. (Submitted for publication) Lane N, Kaplan H, Pascal R (1971) Minute adenomatous and hyperplastic polyps of the colon: Divergent patterns of epithelial growth with specific associated mesenchymal changes.

They point out that very small exclusively villous polyps do exist, as do large and strictly tubular adenomas, and feel that different mechanisms account for the two patterns. Earlier workers (see Grinnell & Lane, 1958) suggested that the growth stimulus in VA acts mainly on the surface cells, whereas in TA it acts on mid- or deep crypts. , 1974; Maskens, 1979). Wiebecke et al. (1974) suggested that villous adenomas resulted from vertical "foliaceous" growth with groovelike lengthening of crypts.

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